HLA-DRB1*01:03 allele linked to severe disease requiring hospitalization, major operation, systemic corticosteroid use
By Elana Gotkine HealthDay Reporter
FRIDAY, Oct. 18, 2024 (HealthDay News) — For patients with ulcerative colitis, the HLA-DRB1*01:03 allele is associated with severe ulcerative colitis, according to a research letter published online Oct. 15 in the Journal of the American Medical Association to coincide with the United European Gastroenterology Week, held from Oct. 12 to 15 in Vienna.
Marie Vibeke Vestergaard, from Aalborg University in Denmark, and colleagues conducted a Danish nationwide genome-wide association study on severe versus less severe ulcerative colitis to identify biomarkers using data from a combined cohort of 4,491 patients (4,153 from the neonatal blood spot cohort [NBS] and 338 from the North Denmark Biobank study [NorDIBD]).
The researchers found that a chromosome 6 locus within the HLA region was significantly associated with severe versus less severe ulcerative colitis from 9,508,878 tested single-nucleotide variations (odds ratio, 2.23). The HLA-DRB1*01:03 allele explained this association (odds ratio, 3.32 overall; 3.29 for NBS and 3.98 for NorDIBD). No other allele had a P value below the genome-wide significance threshold. The association with the HLA-DRB1*01:03 allele had odds ratios of 6.38, 5.24, and 2.30 for major operation, at least two hospitalizations, and use of at least 5,000 mg of systemic corticosteroids for carriers versus noncarriers. For carriers versus noncarriers, the hazard ratios were 2.22, 5.13, and 1.69 for time to hospitalization, time to major operation, and time to first treatment with systemic corticosteroids, respectively.
“Given the low cost of typing a single HLA allele, HLA-DRB1*01:03 could be a valuable tool for risk assessment of patients with ulcerative colitis at diagnosis,” the authors write.
Two authors disclosed ties to the pharmaceutical industry.
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