Longer mean duration of quality-adjusted time without symptoms of disease progression or toxicity of treatment seen with dostarlimab
By Elana Gotkine HealthDay Reporter
MONDAY, June 9, 2025 (HealthDay News) — For patients with advanced or recurrent endometrial cancer, dostarlimab plus carboplatin-paclitaxel treatment is associated with improved survival and maintenance of quality of life, according to a study published online May 21 in the International Journal of Gynecological Cancer.
Dana M. Chase, M.D., from the David Geffen School of Medicine at the University of California, Los Angeles, and colleagues randomly assigned patients with primary advanced or recurrent endometrial cancer to receive dostarlimab/placebo plus carboplatin-paclitaxel chemotherapy every three weeks for six cycles followed by dostarlimab/placebo monotherapy every six weeks for up to three years. Data were used from the first interim analysis (Sept. 28, 2022) and quality of life was assessed with the EuroQoL 5-Dimensions 5-Level questionnaire.
Overall, 241 and 246 patients in the dostarlimab and placebo arms, respectively, were analyzed for safety. The researchers found that the mean duration of quality-adjusted time without symptoms of disease progression or toxicity of treatment was significantly longer in the dostarlimab arm than the placebo arm in the overall population (24.75 versus 20.34 months). Regardless of mismatch repair/microsatellite instability status or toxicity criteria used, benefits in quality-adjusted time without symptoms of disease progression or toxicity of treatment were observed after dostarlimab treatment; benefits were mainly driven by time without symptoms of disease.
“This is the first study to demonstrate a statistically significant improvement in both overall survival and quality-adjusted survival with an immunotherapy-chemotherapy combination in this disease setting,” Chase said in a statement. “It’s a major step forward in the treatment of endometrial cancer.”
Several authors disclosed ties to pharmaceutical companies, including GlaxoSmithKline, which manufactures dostarlimab and funded the study.
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