Unvaccinated patients had higher rate of continuous renal replacement therapy during hospitalization and higher rate of being discharged on RRT
By Elana Gotkine HealthDay Reporter
WEDNESDAY, June 18, 2025 (HealthDay News) — For patients hospitalized with COVID-19 infection and acute kidney injury (AKI), those who are unvaccinated have worse outcomes in terms of kidney function and mortality, according to a study published online June 17 in Kidney Medicine.
Niloofar Nobakht, M.D., from the David Geffen School of Medicine at the University of California Los Angeles, and colleagues conducted a single-center cohort study involving 972 adult patients admitted with COVID-19 infection and AKI from March 1 to March 30, 2022. Of these, 42.3 and 48.0 percent had not received a dose of a U.S.-approved COVID-19 vaccine and had completed the primary vaccine series, respectively.
The researchers found that compared with vaccinated patients, unvaccinated patients had a higher rate of requiring continuous renal replacement therapy (CRRT) during their hospitalization (15.8 versus 10.9 percent). There was a significant association for CRRT during hospitalization with in-hospital death and long-term follow-up death (adjusted hazard ratios, 2.82 and 2.44, respectively). Compared with those who were vaccinated, unvaccinated patients had 2.56-fold higher odds of being discharged on renal replacement therapy. In an adjusted multivariable analysis, significantly increased in-hospital mortality and long-term follow-up mortality were seen for those who were unvaccinated versus those who were vaccinated (adjusted hazard ratios, 5.54 and 4.78, respectively).
“The COVID-19 vaccine is an important intervention that can decrease the chances of developing complications from the COVID-19 infection in patients hospitalized with acute kidney injuries,” Nobakht said in a statement.
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